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Digital KO Twin — QC → QA → RCA

What the Twin does today, how it decides, and why this is the highest‑leverage slice of the CRISPR‑KO pipeline.

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Off‑Target preview

  • Quick genome mapping for candidate sites.
  • Gene + exon context for each hit.
  • Use to triage risk fast.

Allele Spectrum

  • Top indels and frequencies.
  • Frameshift vs in‑frame summary.
  • Sanger/NGS friendly view.

Functional QC

  • Frameshift % and residual WT.
  • Read depth and alignment checks.
  • Clear pass/partial/fail.

Confidence Rules

  • Thresholds you can tune.
  • Sanger + NGS agreement shown.
  • Transparent guardrails.

RCA guidance

  • Likely cause of failure.
  • Next step suggestions.
  • Design/Delivery/Off‑site/Identity.

Export & provenance

  • PDF for review.
  • ELN/LIMS‑ready JSON.
  • Versions + file hashes inside.